Imran, Muhammad http://orcid.org/0000-0002-4712-6634
Bhatti, Aasia
King, David M.
Lerch, Magnus
Dietrich, Jürgen http://orcid.org/0000-0002-5494-3499
Doron, Guy http://orcid.org/0000-0003-1252-5747
Manlik, Katrin http://orcid.org/0000-0003-3647-5326
Article History
Accepted: 13 February 2022
First Online: 17 May 2022
Declarations
:
: This experiment was conducted during a project at Bayer AG that involved consultancy work carried out by Magnus Lerch. Magnus Lerch has received compensation for consultancy work from Bayer AG.
: Aasia Bhatti holds shares in Bayer AG. Muhammad Imran, Aasia Bhatti, David King, Magnus Lerch, Jürgen Dietrich, Guy Doron, and Katrin Manlik have no conflicts of interest that are directly relevant to the content of this experiment. Muhammad Imran, Jürgen Dietrich, Guy Doron, and Katrin Manlik are full-time employees of Bayer AG. Aasia Bhatti and David King are full-time employees of Bayer US LLC. The views expressed in this article are those of the authors and do not necessarily reflect the official policies or position of Bayer AG, Bayer US LLC or Lenolution GmbH.
: Not applicable.
: Not applicable.
: Not applicable.
: The datasets generated during the experiment were retrieved from Bayer’s safety database and contain private patient information that cannot be made publicly available.
: The code used for this experiment is proprietary and therefore cannot be provided.
: Muhammad Imran, Aasia Bhatti, David King, Magnus Lerch, Jürgen Dietrich, and Guy Doron were involved in the conception and design of the experiment in phase I and phase II. Katrin Manlik was involved in the conception and design of the experiment in phase II. Muhammad Imran was responsible for the design and implementation of data processing, feature engineering pipeline, the ML models, the interpretation and presentation of the results, and the implementation of SHAP analysis. All authors contributed to the interpretation of the data analysis results and assisted with the concept and draft revisions of the manuscript. Guy Doron and Jürgen Dietrich assisted with literature search and review. All authors reviewed and approved the final manuscript and accept full responsibility for its overall content.