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Article History

Accepted: 27 February 2022

First Online: 17 March 2022

Declarations

:

: This study was funded in part by the National Center for Advancing Translational Sciences, National Institutes of Health through UCSF-CTSI (#UL1 TR991872).

: The authors have no conflict of interest. All authors assert that the views expressed in this article are their own and do not necessarily reflect those of any organization with which they may be associated.

: The University of California San Francisco Institutional Review Board approved this study and the waiver of written informed consent (#18-25355).

: Not applicable.

: Not applicable.

: The raw data generated at our institution and analyzed during the current study are not publicly available because of the Health Insurance Portability and Accountability Act. De-identified data may be available from the corresponding author on reasonable request and execution of a data use agreement. The data sources are described in the article.

: Not applicable.

: RRM conceptualized and designed the study, conducted the study, analyzed and interpreted the data, and wrote the first draft of the manuscript. ZL contributed to the study design, analyzed and interpreted the data, and critically revised the manuscript. BT helped interpreting the data and critically revised the manuscript. CLC interpreted the data, helped draft the manuscript, and critically revised the manuscript. ESV helped contribute the study design and data interpretation, and critically revised the manuscript. All authors contributed to manuscript revision and approved the final manuscript.