Article History
Accepted: 29 June 2022
First Online: 15 July 2022
Declarations
:
: None.
: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
: Not applicable, no new patient data was used in this research.
: Not applicable, safety data used is publicly available and consent was obtained during the original research.
: Not applicable, safety data used is publicly available and consent was obtained during the original research.
: The case study data has been deposited at ClinicalTrials.gov under study number NCT00240331. The R-package, a tutorial and the simulation study code can be found at ExternalRef removed.
: Simulation study code and the implementation of the models can be found at ExternalRef removed.
: AR, MH and AZ developed the statistical model and simulation framework. AR conducted the simulation study and data analysis; she also prepared the first draft. MH and AZ edited the manuscript. All authors read and approved this manuscript.