Fusaroli, Michele http://orcid.org/0000-0002-0254-2212
Polizzi, Stefano
Menestrina, Luca
Giunchi, Valentina
Pellegrini, Luca
Raschi, Emanuel
Weintraub, Daniel
Recanatini, Maurizio
Castellani, Gastone
De Ponti, Fabrizio
Poluzzi, Elisabetta
Funding for this research was provided by:
Alma Mater Studiorum - Università di Bologna
Article History
Accepted: 22 July 2024
First Online: 15 August 2024
Declarations
:
: Open access funding provided by Alma Mater Studiorum - Università di Bologna within the CRUI-CARE Agreement.
: The authors declare no conflict of interest specific for this research. Fabrizio De Ponti is an Editorial Board member of Drug Safety. Fabrizio De Ponti was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.
: Not applicable because spontaneous reports of the FAERS are anonymous and publicly available.
: Not applicable because spontaneous reports of the FAERS are anonymous and publicly available.
: Not applicable because spontaneous reports of the FAERS are anonymous and publicly available.
: The data we used come from the FDA Adverse Event Reporting System (FAERS) and is made publicly available by the FDA as quarterly data downloadable at . The algorithm for cleaning FAERS data is open-source at , and the cleaned database is available on an OSF repository [] and through the R package DiAna [].
: The code for the project is available on an OSF repository [], the function for the Ising network is also available in the DiAna package (cfr. “network_analysis()”) []. Analyses were performed using R (version 4.2.1) [] and Python (version 3.8.16) []. We relied on several essential packages for network analysis: <i>IsingFit</i> [], <i>igraph</i> [], <i>psych</i> [], and <i>bnlearn</i> [].
: MF, SP, LM, conceptualized and designed the study. MF, SP, LM developed the methodology. The formal analysis was performed by MF, SP, LM, VG. MF, SP, VG performed the visualization. MF, SP, LM, VG wrote the original draft. All the authors strongly contributed to the interpretation of results, and to the review and editing of the draft. All the authors read and approved the final version.