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Authors
Allen, Matthew R. https://orcid.org/0009-0003-6372-9405
Wightman, Gwenyth Portillo
Zhu, Zechariah
Poliak, Adam
Smith, Davey M.
Dredze, Mark
Ayers, John W.
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Funding
Funding for this research was provided by:
Burroughs Wellcome Fund
U.S. Food and Drug Administration (Johns Hopkins University Center of Excellence in Regulatory Science, Innovation)
National Center for Advancing Translational Sciences (UL1TR001442)
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Article History
Accepted: 22 August 2024
First Online: 18 September 2024
Declarations
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: This work was supported by the US FDA via the Johns Hopkins University Center of Excellence in Regulatory Science and Innovation, the Burroughs Wellcome Fund, and the National Center for Advancing Translational Sciences (grant UL1TR001442). The funders played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
: Matthew R. Allen, and Zechariah Zhu report no conflicts of interest that may be relevant to the contents of this study. Gwenyth Portillo Wightman is a data scientist at Astrana Health. Adam Poliak reports paid consulting for Pearson Education, Inc. and was previously a paid intern for Bloomberg LP. Davey M. Smith has consulted for Linear Therapies, Model Medicines, Bayer Pharmaceuticals, Kiadis Pharmaceuticals, Lucira, Gilead, Red Queen Therapeutics, Hyundai and Vx Biosciences. Mark Dredze holds equity in Good Analytics and has received consulting fees from Bloomberg LP. John W. Ayers owns equity positions in Health Watcher and Good Analytics.
: All analyses used Python 3.10.5, adhered to Reddit’s terms and conditions, and were determined by the Johns Hopkins University human research protections program to be exempt because the study used public, non-identifiable data.
: Not applicable.
: Not applicable.
: Replication files are publicly available on Dataverse at . Individual post content is not shared per Reddit's terms of service. Post contents can be accessed via the Reddit API.
: Code will be made available upon reasonable request to the corresponding author.
: MRA provided clinical context and led the study design jointly with JWA. GPW and ZZ led the data collection, annotation, and analysis; DMS provided clinical context and contributed intellectual value to the manuscript. All authors have read and agreed to the final submission.
