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Article History

Accepted: 9 February 2025

First Online: 13 March 2025

Declarations

:

: Funding for this project was provided by Luto Research, UK. Sponsors were involved in manuscript writing and editing.

: Author MS reports grants from Merck, the Gordon and Betty Moore Foundation, the NIH, and Eli Lilly outside the submitted work; and personal fees from Sanofi, Pfizer, GlaxoSmithKline, Lundbeck, Bristol Myers Squib, and Luto outside the submitted work. Authors CM and WM are employees of Luto Research, UK. All other authors report no conflicts of interest.

: Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

: Not applicable—review article.

: Not applicable—review article.

: Not applicable—review article.

: Not applicable—review article.

: Conceptualization (AR, RL, WM, MW), data curation (AR, RL, AV, DN), formal analysis (AR, RL, AV, MW), funding acquisition (AR, MW), methodology (AR, RL, AV, DN, MW, CM, WM), visualization (AR, DN), writing—original draft (AR, RL, AV, DN, CM, WM, MW). All authors have read and approved the final version of the manuscript and agree to be accountable for the work.