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Article History

Accepted: 11 March 2025

First Online: 9 April 2025

Declarations

:

: This study was conducted by researchers at RTI Health Solutions, an independent nonprofit research organization. Funding for the research was received from Acadia Pharmaceuticals Inc., the manufacturer of pimavanserin. The contract between RTI Health Solutions and Acadia Pharmaceuticals Inc. includes independent publication rights.

: V.A. and D.D. are employees of Acadia Pharmaceuticals Inc., the manufacturer of pimavanserin. S.R., L.J.M., J.F., H.E.D., R.M., M.S.A., and J.B.L. are employed by RTI Health Solutions.

: This study was performed using US Medicare data accessed through Medicare Research Identifiable Files, which were available for use upon approval and licensing under a data use agreement between the US Centers for Medicare and Medicaid Services (CMS) and RTI Health Solutions. The authors are not authorized to release data based on CMS privacy policies. However, data are available with permission from CMS () upon the establishment of a data use agreement.

: Not applicable.

: This analysis was determined to be exempt from full institutional review board review by the RTI International (RTI) institutional review board on 14 December 2020 (RTI IRB Study ID 00021361). The US CMS Privacy Board approved the use of Medicare Research Identifiable Files for this study under a data use agreement with RTI Health Solutions.

: The RTI IRB determined that individual-level consent was not required for this analysis of secondary, deidentified data.

: Not applicable.

: S.R., J.B.L., and J.F. contributed to the conceptualization, investigation, methodology, visualization, and writing of the original draft. H.E.D. and R.M. contributed to the resources, project administration, investigation, and writing for the review and editing drafts of the manuscript. L.J.M. contributed to the methodology, software, formal analysis, data curation, and writing for the review and editing drafts of the manuscript. D.D. and V.A. contributed to the investigation and writing for the review and editing drafts. M.S.A. contributed to the conceptualization, supervision, investigation, methodology, funding acquisition, and writing of the review and editing drafts. All authors have read and approve the final version of the manuscript and agree to be accountable for the work.