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Article History

Accepted: 5 May 2025

First Online: 30 June 2025

Declarations

:

: This study was funded by Appel d’Offre Epiphare 2023.

: No commercial organizations had any role in the writing of this paper for publication. Alice Lopez, Chiara Alfarano, Marianne Lepetit, Leila Chebane, Nassima Redjimi, Anaïs Couret, Didier Fabre, Virginie Gardette, Driss Berdaï, Maryse Lapeyre-Mestre, and Haleh Bagheri have no conflicts of interest that are directly relevant to the content of this article.

: Strict confidentiality was ensured at all times during data collection, storage, and analysis. All methods were carried out in accordance with relevant guidelines and regulations. According to the French Ethics and Regulatory law (public health code), retrospective/prospective studies based on the exploitation of usual care data do not have to be submitted to an ethics committee, but they must be declared or covered by the reference methodology of the French National Commission on Informatics and Liberties (CNIL). A collection and computer processing of personal and medical data was implemented to analyze the results of the research. Toulouse University Hospital signed a commitment of compliance to the reference methodology MR-004 of CNIL. After evaluation and validation by the data protection officer and according to the General Data Protection Regulation, this study completing all the criteria, it is registered in the register of data study of the Toulouse University Hospital (RnIPH 2022-192) and covered by the MR-004 (CNIL number: 2206723 v 0). This study was approved by Toulouse University Hospital who confirms that ethics requirements were totally respected in the above report. According to French law on ethics, clinical trials covered by reference methodology MR-004, patients were informed that their codified data will be used for the study; written consent is not required.

: Not applicable.

: Not applicable.

: Data sharing is not applicable to this article as the datasets used are based on anonymized data that are protected by agreements with the French Data Protection Commission (CNIL).

: R version 4.4.1 (2024-06-14 ucrt), ""Race for Your Life" Copyright 2024, The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64.

: AL and CA contributed to the data collection, analysis of patient records and medications, analysis and interpretation of data, drafting of the manuscript, and critical revision. ML contributed to the data base adjustments, statistical analysis of data, and manuscript revision. LC contributed to database entry and optimization. NR contributed to the acquisition of data (arranging), database entry, and patient record archiving. DF contributed to the acquisition of data (arranging and obtaining) and patient records. VG and DB contributed to critical revision of the manuscript. ML contributed to the conception, design, and methodology, statistical analysis and interpretation of the data, and critical revision of the manuscript. HB contributed to the conception, design and methodology, data collection and analysis supervision, writing manuscript and critical revision, and team coordination. All authors read and approved the final version.