Document is current

Article History

Received: 25 August 2025

Accepted: 19 November 2025

First Online: 5 December 2025

Declarations

:

: Thomas Delvin reports being an employee of LEO Pharma A/S. Anette Bygum reports involvement in research and educational activities with Takeda, CSL Behring, Biocryst, Eli Lilly, Pierre Fabre, and Sanofi. Lars Christian Lund reports participation in research projects funded by Menarini Pharmaceuticals and LEO Pharma; all funds were paid to the institution where he was employed (no personal fees), and these projects had no relation to the current work. Jacob Harbo Andersen reports no conflicts of interest. Jesper Hallas reports participation in research projects funded by Alcon, Almirall, Astellas, Astra-Zeneca, Boehringer-Ingelheim, Novo Nordisk, Servier, and LEO Pharma; all funds were paid to the institution where he was employed (no personal fees), and these projects had no relation to the current proposal.

: According to Danish law, studies based entirely on registry data do not require approval from an ethics review board.

: Data were accessed and analyzed within the data environment provided by the Danish Health Data Authority.

: Not applicable. This study was based entirely on anonymized national registry data, for which individual patient consent is not required under Danish law.

: Not applicable.

: Data were accessed and analyzed within the secure data environment provided by the Danish Health Data Authority. Due to Danish data protection regulations protecting patient privacy, raw data cannot be made publicly available or shared. Access to the underlying data can be granted to eligible researchers upon successful application to the Danish Health Data Authority.

: Not applicable.

: All authors made substantial contributions to the conception or design of the work, or the acquisition, analysis, or interpretation of data for the work; drafted the work or reviewed it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. JH Andersen, T Delvin, and J Hallas had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The authors report the use of Google's Gemini (version 2.5 PRO) on several occasions between April 15, 2025, and May 25, 2025, to assist with linguistic fine-tuning and language polishing of the manuscript. The authors take full responsibility for the integrity of the content generated and all final wording.

: The protocol was pre-registered at the Real-World Evidence Registry and the Open Science Framework before final analysis ( ).