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Article History

Accepted: 25 October 2023

First Online: 15 November 2023

Declarations

:

: Not applicable.

: Daniel Tewkesbury, Rowland Bright-Thomas, Alyn Cratchley, Karen Piper Hanley and Judith Wyatt have no conflicts of interest to declare. Andrew M. Jones has accepted speaker fees from Vertex pharmaceuticals; Varinder Athwal has accepted speaking fees and honoraria from Vertex pharmaceuticals and Roche diagnostics; and Peter J. Barry has accepted speaking fees and honoraria from Vertex pharmaceuticals and advisory board fees from INSMED.

: Data sharing is not applicable to this article as no datasets were generated during this study. All clinical data analysed are included in this article.

: This work received approval from the institutional information governance department.

: Not applicable.

: Written consent was obtained from individuals to publish and share liver histology images.

: Not applicable.

: DT<b>:</b> conceptualization, methodology, formal analysis, investigation, writing—original draft, visualization. VA: conceptualization, supervision, writing—review and editing. RBT: conceptualization, writing—review and editing, supervision. AC: formal analysis, writing—review and editing. KPH: supervision, writing—review and editing. AJ: Conceptualization, writing—review and editing, supervision. JW: formal analysis, writing—review and editing. PB: conceptualization, writing—review and editing, supervision.