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Article History

Received: 30 March 2025

Accepted: 12 August 2025

First Online: 30 August 2025

Change Date: 11 September 2025

Change Type: Update

Change Details: The original article has been updated to update the equally contributed.

Declarations

:

: Open access funding provided by Alma Mater Studiorum - Università di Bologna within the CRUI-CARE Agreement.

: Conceptualization: AFGC and FF. Data curation: AFGC, GT, AA, PP, GN, FP, CB, and FF. Investigation: AFGC, GT, AA, PP, and FF. Methodology: AFGC, GT, AA, PP, GN, FP, CB, and FF. Project administration: AFGC, GT, and FF. Supervision: AFGC and FF. Visualization: AA, FP, and FF. Writing: AFGC, GT, AA, PP, and FF. Reviewing and editing: GN, FP, and CB

: Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

: Claudio Borghi has received personal fees from Servier Pharma, EGIS Pharma, the Menarini Group, and Mineralys Therapeutics. Arrigo FG Cicero, Giuliano Tocci, Ashot Avagimyan, Peter Penson, Giulia Nardoianni, Francesco Perone, and Federica Fogacci have no potential conflicts of interest that might be relevant to the contents of this manuscript.

: Not applicable.

: Not applicable.

: Not applicable.

: Not applicable.