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Article History

Accepted: 7 January 2021

First Online: 22 February 2021

Declarations

:

: This study was funded by the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) collaborative group. All medical writing assistance was funded by the Spanish Cooperative TTD and Roche Farma SA.

: E Díaz Rubio has received grants from SYSMEX, Merck Serono, Roche, AstraZeneca and Amgen. A Carrato is an advisory board member for Merck, Roche, MSD, Pfizer, Bayer, Shire, Servier, Celgene and Amgen and has received research funds from Celgene, Shire and Amgen. B Massutí has received payment for consulting or advisory roles from Roche, Boehringer Ingelheim, Bristol-Myers Squibb, Merck Sharpe and Dohme and AstraZeneca; participating in speakers' bureau from Roche, Amgen, Merck Serono, Pfizer, AstraZeneca and Boehringer Ingelheim; and travel, accommodation or expenses from Boehringer Ingelheim, Merck Sharp and Dohme, Janssen and Roche. A Muñoz has received grants from Sanofi, Celgene, Leo Pharma; non-financial support from Merck Serono; personal fees and non-financial support from Sanofi, Celgene, Roche and Amgen; and personal fees from AstraZeneca, Leo Pharma, Servier, Pfizer, Daiichi Sankyo, Bayer and Halozyme, Merck Sharp and Dohme, Rovi and Lilly. J Sastre has received honoraria for speaking roles with Merck, Roche, Ipsen, Lilly, Shire, Pfizer, Servier and MSD; advisory roles with Roche, Amgen, Merck, Bayer, Celgene, Servier, BMS, Sanofi and Ipsen; and travelling and accommodation support from Merck and Ipsen. R Ferreiro has received honoraria for speaking and advisory roles and personal fees and travelling and accommodation support from Roche, Amgen and Servier. M Valladares-Ayerbes has received grants from Roche and personal fees from Roche, Merck, Amgen, Sanofi, Servier, Bayer and Celgene. JM Viéitez has received payments for consulting or advisory roles from Roche, Amgen and Servier; travel, accommodation and expenses from Roche, Amgen, Servier and Bristol-Myers Squibb; expert testimony from Servier; and research funding from Amgen and Roche. E Aranda has received honoraria for advisory roles from Amgen, Bayer, Celgene, Merck, Roche and Sanofi. P García Alfonso, A Abad, MJ Ortiz-Morales, JL Manzano Mozo, G Durán, MJ Safont, F Rivera, E González, C Grávalos, V AlonsoOrduña and A Yubero have no conflicts of interest that are directly relevant to the content of this article.

: All studies included in this retrospective analysis were conducted in accordance with the Declaration of Helsinki and were approved by institutional review boards or independent ethics committees at each centre.

: All patients gave written informed consent to participate in these studies.

: The datasets generated and analysed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: Conception/design: P García Alfonso. Provision of study material or patients: all authors. Collection and/or assembly of data: all authors. Data analysis and interpretation: P García Alfonso. Manuscript preparation: P García Alfonso. Final approval of manuscript: all authors.