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Authors
Pagès, Arnaud https://orcid.org/0000-0002-2337-8693
Costa, Nadège
Mounié, Michaël
Cestac, Philippe
De Souto Barreto, Philipe
Rolland, Yves
Vellas, Bruno
Molinier, Laurent
Juillard-Condat, Blandine
,
Vellas, Bruno
Guyonnet, Sophie
Carrié, Isabelle
Brigitte, Lauréane
Faisant, Catherine
Lala, Françoise
Delrieu, Julien
Villars, Hélène
Combrouze, Emeline
Badufle, Carole
Zueras, Audrey
Andrieu, Sandrine
Cantet, Christelle
Morin, Christophe
Van Kan, Gabor Abellan
Dupuy, Charlotte
Rolland, Yves
Caillaud, Céline
Ousset, Pierre-Jean
Lala, Françoise
Willis, Sherry
Belleville, Sylvie
Gilbert, Brigitte
Fontaine, Francine
Dartigues, Jean-François
Marcet, Isabelle
Delva, Fleur
Foubert, Alexandra
Cerda, Sandrine
Cuffi, Marie-Noëlle
Costes, Corinne
Rouaud, Olivier
Manckoundia, Patrick
Quipourt, Valérie
Marilier, Sophie
Franon, Evelyne
Bories, Lawrence
Pader, Marie-Laure
Basset, Marie-France
Lapoujade, Bruno
Faure, Valérie
Tong, Michael Li Yung
Malick-Loiseau, Christine
Cazaban-Campistron, Evelyne
Desclaux, Françoise
Blatge, Colette
Dantoine, Thierry
Laubarie-Mouret, Cécile
Saulnier, Isabelle
Clément, Jean-Pierre
Picat, Marie-Agnès
Bernard-Bourzeix, Laurence
Willebois, Stéphanie
Désormais, Iléana
Cardinaud, Noëlle
Bonnefoy, Marc
Livet, Pierre
Rebaudet, Pascale
Gédéon, Claire
Burdet, Catherine
Terracol, Flavien
Pesce, Alain
Roth, Stéphanie
Chaillou, Sylvie
Louchart, Sandrine
Sudres, Kristel
Lebrun, Nicolas
Barro-Belaygues, Nadège
Touchon, Jacques
Bennys, Karim
Gabelle, Audrey
Romano, Aurélia
Touati, Lynda
Marelli, Cécilia
Pays, Cécile
Robert, Philippe
Duff, Franck
Gervais, Claire
Gonfrier, Sébastien
Gasnier, Yannick
Bordes, Serge
Begorre, Danièle
Carpuat, Christian
Khales, Khaled
Lefebvre, Jean-François
El Idrissi, Samira Misbah
Skolil, Pierre
Salles, Jean-Pierre
Dufouil, Carole
Lehéricy, Stéphane
Chupin, Marie
Mangin, Jean-François
Bouhayia, Ali
Allard, Michèle
Ricolfi, Frédéric
Dubois, Dominique
Martel, Marie Paule Bonceour
Cotton, François
Bonafé, Alain
Chanalet, Stéphane
Hugon, Françoise
Bonneville, Fabrice
Cognard, Christophe
Chollet, François
Payoux, Pierre
Voisin, Thierry
Delrieu, Julien
Peiffer, Sophie
Hitzel, Anne
Allard, Michèle
Zanca, Michel
Monteil, Jacques
Darcourt, Jacques
Molinier, Laurent
Derumeaux, Hélène
Costa, Nadège
Perret, Bertrand
Vinel, Claire
Caspar-Bauguil, Sylvie
Olivier-Abbal, Pascale
Andrieu, Sandrine
Cantet, Christelle
Coley, Nicola
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Clinical trials referenced in this document:
nct00672685 at ClinicalTrials.govDocuments that mention this clinical trial
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https://doi.org/10.1016/s0140-6736(16)30950-3
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Funding
Funding for this research was provided by:
Occitanie/Pyrénées-Méditerranée Region (1901175)
European Regional Development Fund (MP0022856)
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Article History
Accepted: 19 April 2022
First Online: 24 May 2022
Declarations
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: Arnaud Pagès, Nadège Costa, Michaël Mounié, Philippe Cestac, Philipe De Souto Barreto, Yves Rolland, Bruno Vellas, Laurent Molinier, and Blandine Juillard-Condat declare they have no conflicts of interest.
: The MAPT study was supported by grants from the Gérontopôle of Toulouse, the French Ministry of Health (PHRC 2008, 2009), Pierre Fabre Research Institute (manufacturer of the omega-3 supplement), ExonHit Therapeutics SA, and Avid Radiopharmaceuticals Inc., while the ECO-MAPT study was supported by grants from the French Ministry of Health (PHRC 2008) and the France Alzheimer Association (Doctoral Scholarship 2010). The MAPT study was sponsored by the University Hospital of Toulouse. The data sharing activity was supported by the Association Monegasque pour la Recherche sur la maladie d’Alzheimer (AMPA) and the UMR 1295 Unit INSERM-University of Toulouse III.
: The trial protocol was approved by the French Ethical Committee for the Protection of Persons (CPP SOOM II) and was authorized by the French National Agency for Medicines and Health Products Safety. The trial was registered in ClinicalTrials.gov (NCT00672685). This specific secondary analysis was approved for ethics and feasibility by the Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer (MAPT/DSA) Group.
: The authors affirm that human research participants provided informed consent for publication of their data.
: All participants were recruited by the investigators, who verified inclusion and exclusion criteria and obtained written informed consent.
: The MAPT data are available upon request, following validation of a research proposal, from Nicola Coley (nicola.coley@inserm.fr) or Sophie Guyonnet (guyonnet.s@chu-toulouse.fr).
: The code is available upon request from pages.ar@chu-toulouse.fr.
: All authors were involved in the conception and design of the study as well as data interpretation. AP, NC, and MM were involved in collecting the data. AP and MM were involved in the statistical analyses. AP, NC, MM, and BJC were involved in preparing and revising the manuscript. NC, BJC, LM, PC, YR, BV, and PDSB provided essential advice on the focus of the analysis, methodology, and clinical and economic impacts. All authors have read and agreed to the published version of the manuscript.
