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Article History

Accepted: 22 June 2022

First Online: 15 September 2022

Declarations

:

: The iKASCADE project is funded by “Identifying Key Prescribing CASCADes in the Elderly: A Transnational Initiative on Drug Safety” (GNP-1782), GENDER-NET Plus ERA-Net Cofund: “Promoting gender equality in H2020 and the ERA”, in Partnership with: the Canadian Institutes of Health Research-Institutes of Gender & Health and Institute of Aging; the Irish Research Council; Ministerodella Salute (Italy); and Ministry of Science and Technology (Israel). Dr. Paula Rochon holds the RTOERO Chair in Geriatric Medicine at the University of Toronto. The sponsor was not involved in the design, methods, subject recruitment, data collection, analysis, or preparation of the manuscript.

: The authors have no conflicts of interest that are directly relevant to the content of this study.

: The Research Ethics Board at Women’s College Hospital approved this study (2019-0188-E).

: All panelists consented to participate. Panelists listed in the Supplementary material (eAppendix 4 of the ESM) consented to publication of their names and jurisdictions.

: Not applicable.

: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: Not applicable.

: PAR and LMM have full access to all study data; LMM takes responsibility for the integrity of the data and accuracy of the data analyses. Concept and design: PAR, LMM, RS, RM, AL, JL, WW, and the iKASCADE team. Acquisition, analysis or interpretation of the data: all authors. Drafting of the manuscript: LMM, RS, KD, JL, AL, RM, and PAR. Critical revision of the manuscript for important intellectual content: all authors. Statistical analysis: WW. Administrative, technical or material support: LMM, JL, AL, and PAR. Supervision: LMM and PAR.