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Article History

Accepted: 7 December 2022

First Online: 13 January 2023

Declarations

:

: Open Access funding enabled and organized by Projekt DEAL. We received no external funding for the conduct of this study.

: WEH received consulting honoraria, speaker’s honoraria, and travel support from Bristol-Myers Squibb GmbH & Co. KGaA, Boehringer Ingelheim Pharma GmbH & Co. KG, and Daiichi Sankyo GmbH as well as research support from Bayer AG and Daichii Sankyo GmbH, outside the submitted work. DC received consulting honoraria, speaker’s honoraria, and travel support from Daichii-Sankyo, outside the submitted work. JMB received consulting honoraria from Nestlé and Danone Nutricia and speaker’s honoraria from Nestlé, Danone Nutricia, Fresenius, Bayer, Pfizer, Novartis, Daiichi Sankyo, and UCB Pharma, outside the submitted work. AE, JM, PB, KIF, JB, FS, AB, and GM have no conflicts of interest that are directly relevant to the content of this article.

: The study was approved by the Ethics Committee of the Medical Faculty of Heidelberg University (S-866/2018).

: Written informed consent was obtained from each participant included in the study.

: Not applicable.

: The authors confirm that all relevant data are included in the article and/or its supplementary information files.

: Not applicable.

: Conceptualization: AE, JM, DC, AB, GM, WEH, JMB; data curation: AE, JM, KIF, JB; formal analysis: AE, JM, PB, DC, FS, GM, WEH, JMB; funding acquisition: WEH, JMB; investigation: AE, JM, KIF; project administration: AE, JMB; resources: JB, WEH, JMB; supervision: GM, JMB; visualization: AE, GM, WEH; writing, original draft: AE; writing, review and editing: AE, JM, PB, KIF, JB, DC, FS, AB, GM, WEH, JMB. All authors read and approved the final version of the manuscript.