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Article History

Accepted: 28 April 2025

First Online: 2 June 2025

Declarations

:

: Open access funding provided by Università degli Studi di Roma Tor Vergata within the CRUI-CARE Agreement. This study was funded by Amgen (Europe) GmbH.

: Myriam Dilecce, Massimo Spelta, and Susan Sammak are employees of Amgen. The other authors declare they have no conflicts of interest to disclose.

: When reporting a study that involved human participants, their data or biological material, authors should include a statement that confirms that the study was approved (or granted exemption) by the appropriate institutional and/or national research ethics committee (including the name of the ethics committee, approval number, date of approval, and time period in which the study was conducted) and certify that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

: According to General Authorization for the Processing of Personal Data for Scientific Research Purposes issued by the Italian Privacy Authority on August 10, 2018 (Available at ) this study was exempt from informed consent.

: Not applicable.

: The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request.

: Not applicable.

: Study conception and design: Matteo Scortichini and Paolo Sciattella. Data collection: Salvatore Riegler and Fausto Bartolini. Analysis and interpretation of results: Matteo Scortichini and Paolo Sciattella. Draft manuscript preparation: Matteo Scortichini and Paolo Sciattella. All authors reviewed the results and approved the final version of the manuscript.