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Article History

Accepted: 25 October 2021

First Online: 10 November 2021

Declarations

:

: This study was supported by the Ontario Drug Policy Research Network and the Canadian Patient Safety Institute. This study was also supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results and conclusions reported are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions and statements expressed herein are those of the authors and not necessarily those of CIHI. We thank IMS Brogan Inc. for use of their Drug Information Database. The study sponsors provided the operating costs and infrastructure to support the research. No funding bodies had any role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.

: DTW received funding from the Ontario Drug Policy Research Network for this project. TG and MMM received grant funds from the Ontario MOHLTC. KO, DM, PAR, GAE and SSG have no conflicts of interest that are directly relevant to the content of this article.

: Ethics approval was received from Sunnybrook Health Sciences Centre Research Ethics Board, ON, Canada.

: Not applicable.

: Not applicable.

: The study guarantors affirm that this manuscript is an accurate and transparent account of the study being reported, that no important aspects of the study have been omitted, and that any discrepancies from the study as planned (and, if relevant, registered) have been explained. The dataset from this study is held securely in coded form at the ICES. While data-sharing agreements prohibit ICES from making the dataset publicly available, access can be granted to those who meet prespecified criteria for confidential access ().

: All calculations were performed using SAS statistical software (version 6.1, SAS Institute, Cary, NC, USA). Coding is available upon request.

: DTW, KO, TG, DM, MMM, PAR, GAE and SSG conceived and designed the study and carried out the statistical analysis. DTW wrote the manuscript, and all authors contributed to the critical appraisal and review of the manuscript.