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Article History

Accepted: 5 February 2025

First Online: 24 March 2025

Declarations

:

: This study was supported by a Grant-in-Aid (KAKENHI) from the Japan Society for the Promotion of Science (JSPS) [Grant number 24K09959], the Japan Research Foundation for Clinical Pharmacology Grant, and the Research Foundation for Pharmaceutical Sciences.

: The authors have no relevant financial or non-financial interests to disclose.

: The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request.

: This study was approved by the Ethics Committee of the University of Tokushima Hospital (approval number: 4529) and adhered to the protocols outlined in the Declaration of Helsinki.

: Although this analysis does not use personal information such as individual ID, age, sex, or disease title, consent for use and publication of the information was obtained appropriately for eligible patients.

: Data are available on reasonable request.

: Not applicable.

: All authors read and approved the final version. Conceptualization and Methodology: Kenta Yagi, Makoto Kajizono; Data correction and investigation: Akinori Maruo, Wataru Shinmura, Yuuki Nitta, Toshihiko Yoshioka, Masayuki Chuma, Shunsuke Ishida, Tsukasa Higashionna, Hiroaki Tanaka; Data analysis: Akinori Maruo, Toshihiko Yoshioka, Fuka Aizawa, Takahiro Niimura, Mitsuhiro Goda, Kei Kawada; Writing–original draft preparation: Kenta Yagi, Makoto Kajizono; Writing–review and editing: Yuki Izawa-Ishizawa, Yoshito Zamami, Shinji Kosaka, Yoshikazu Tasaki, Keisuke Ishizawa; Funding acquisition: Kenta Yagi, Keisuke Ishizawa; Supervision: Yoshito Zamami, Shinji Kosaka, Yoshikazu Tasaki, Keisuke Ishizawa.