Schafer, Peter H. http://orcid.org/0000-0002-3880-0850
Adams, Mary
Horan, Gerald
Truzzi, Francesca
Marconi, Alessandra
Pincelli, Carlo
Article History
First Online: 9 October 2019
Compliance with Ethical Standards
:
: PH. Schafer, M. Adams, and G. Horan are employees of Celgene Corporation, and have equity ownership; P.H Schafer and M. Adams hold a patent (WO2014074846 A1) for the use of apremilast in the treatment of atopic dermatitis. F. Truzzi, A. Marconi, and C. Pincelli have no conflicts or potential conflicts of interest to disclose.
: This research was supported by Celgene Corporation and the University of Modena and Reggio Emilia.
: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
: PH Schafer and CP conceptualized the research. PHS, MA, and GH performed and analyzed the gene expression studies in stimulated keratinocytes. FT, AM, and CP performed and interpreted the immunohistochemical analysis of the PDE4 isoforms. All of the experiments and analyses related to the two mouse models of atopic dermatitis were contracted to MD Biosciences, St Paul, MN, USA. In addition, all authors have contributed to the critical review and editing, approved this manuscript, and are accountable for the work performed.