Jun, Heajin
Rong, Yan
Yih, Catharina
Ho, Jordan
Cheng, Wendy
Kiang, Tony K. L. http://orcid.org/0000-0003-4548-9746
Funding for this research was provided by:
Mitacs Globalink (#FR41232, #FR41232)
National Research Foundation of Korea (#2019K1A3A1A73079569)
Article History
Accepted: 19 September 2020
First Online: 7 October 2020
Declarations
:
: Heajin Jun was supported by the International Research & Development Program of the National Research Foundation of Korea (Ministry of Science and ICT grant #2019K1A3A1A73079569) and a MITACS Globalink Research Grant (#FR41232) awarded to Heajin Jun and Tony KL Kiang.
: Heajin Jun, Yan Rong, Catharina Yih, Jordan Ho, Wendy Cheng, and Tony KL Kiang have no conflicts of interest that are directly relevant to the content of this article.
: Reasonable requests to access the data should be directed to the corresponding author (Tony KL Kiang, tkiang@ualberta.ca).
: MonolixSuite-2019R2 (Lixoft SAS, Antony, France) and Rsmlx package (Rsmlx, version 2.0.2, Xpop Inria Team) R software v3.6.3 (R Core Team, Vienna, Austria) were used. Requests to access the custom codes for protein-binding models should be directed to the corresponding author (Tony KL Kiang, tkiang@ualberta.ca).
: The study protocol was approved by the University of British Columbia (H18-02215) and the University of Alberta (Pro00100357) research ethics boards. The study was performed in accordance with all ethical standards outlined in the 1964 Declaration of Helsinki and its later amendments.
: As this was a retrospective study, neither consent to participate nor consent to publish were required.
: Wendy Cheng and Tony Kiang conceived the original study design. Retrospective data collection was conducted by Jordan Ho as part of his pharmacy residency project (supervised by Wendy Cheng [primary mentor], Catharina Yih, and Tony Kiang). Non-linear mixed-effects modeling was conducted by Heajin Jun, Yan Rong, and Tony Kiang. The manuscript was drafted by Heajin Jun and Tony Kiang. All listed authors provided feedback and commentary on the submitted draft.