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Article History

Accepted: 8 June 2025

First Online: 8 August 2025

Declarations

:

: This work was supported by the Zhejiang Province Leading Geese Plan (2024C03099) and the Key R&D Program of Hangzhou Science and Technology Bureau (20241203A17).

: The authors affirm that there are no potential conflicts of interest.

: This study was approved by the Medical Ethics Review Committee of Hangzhou Red Cross Hospital (approval number: 2023-002-001).

: All participants in this study voluntarily took part after fully understanding the purpose, process, and potential risks. Before the study began, they signed an informed consent form confirming their understanding of the research, its risks and benefits, and their rights, including the right to withdraw at any time. Participants’ information will be kept confidential, and data will be analyzed anonymously to protect their privacy. This study follows ethical guidelines and has been approved by the ethics committee.

: All authors have consented to the publication of this manuscript. The authors confirm that the manuscript has not been published elsewhere and is not under consideration by any other publication.

: The data that support the findings of this study are available from Neoform Biopharmaceutical Co., Ltd. However, restrictions apply to the availability of these data, as they were used under license for the current study and are not publicly available. Nonetheless, data can be obtained from the corresponding author upon reasonable request and with permission from Neoform Biopharmaceutical Co., Ltd.

: Not applicable.

: Qinjiao Fu wrote the manuscript; Ying Wang, Yingying Xu, and Chunqi Huang designed the research; Yuan Yuan, Yu Wang, and Bin Zhu performed the research; Yanzhu Liu and Fang Tian analyzed the data; Xiufeng Xu and Lei Yang contributed new reagents/analytical tools.