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Article History

Accepted: 26 March 2021

First Online: 19 April 2021

Declarations

:

: This work was supported by the European Union’s Horizon 2020 research and innovation programme [754936]. ENDG was funded by a Rio Hortega contract from the Instituto de Salud Carlos III [CM17/00199]. LMG is funded by a Miguel Servet contract from the Instituto de Salud Carlos III [CP18/00007]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

: Ena Niño de Guzmán Quispe, Laura Martínez García, Carola Orrego Villagrán, Monique Heijmans, Rosa Sunol, David Fraile-Navarro, Javier Pérez-Bracchiglione, Lyudmil Ninov, Karla Salas-Gama, Andrés Viteri García, and Pablo Alonso-Coello have no conflicts of interest that are directly relevant to the content of this article.

: Ethical approval was obtained from the Clinical Research Ethics Committee of the Avedis Donabedian Research Institute, the coordinator partner of the COMPAR-EU Project (EU 754936), and the University Institute for Primary Care Research (IDIAP Jordi Gol) and was signed on March 2018.

: Not applicable.

: Not applicable.

: All the findings from the available data have been published in this manuscript.

: ENDG, LMG, and PAC made substantial contributions to the conception and design of the study. ENDG, DF, JP, KS, and AVG collected all relevant data related to the studies. ENDG, LMG, RS, MH, COV, DF, JP, LN, KS, AVG, and PAC discussed and interpreted the results. ENDG, LMG, and PAC wrote the first draft of the manuscript. All authors revised the manuscript critically for important intellectual content and approved the final version submitted.