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Article History

Accepted: 21 November 2021

First Online: 24 March 2022

Declarations

:

: This work was supported by the Canadian Institutes for Health Research (Canada) [Grant number 381280]; Genome Canada (Canada) [OGI-150]; ZonMw (The Netherlands); and ReumaNederland (The Netherlands). DAM is supported by the Arthur J.E. Child Chair in Rheumatology and a Canada Research Chair in Health Systems and Services Research (2008–2018). SB is supported by the Husky Energy Chair in Child and Maternal Health and the Alberta Children’s Hospital Foundation Chair in Pediatric Research. RSMY is supported by the Hak-Ming and Deborah Chiu Chair in Paediatric Translational Research, The Hospital for Sick Children, University of Toronto. GSH is supported by a Canadian Institutes of Health Research (CIHR) New Investigator Award.

: Gillian R. Currie, Tram Pham, Marinka Twilt, Maarten J. IJzerman, Pauline M. Hull, Michelle M.A. Kip, Susanne M. Benseler, Glen S. Hazlewood, Rae S.M. Yeung, Nico M. Wulffraat, Joost F. Swart, Sebastian J. Vastert, and Deborah A. Marshall declare that they have no conflicts of interest relevant to the contents of this article.

: Ethics approval was obtained from the Conjoint Health Research Ethics Board at the University of Calgary (REB19-0360).

: The ethics approval and consent for this study preclude the sharing of the raw data.

: Not applicable.

: Not applicable.

: Not applicable.

: All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by GRC, TP, and PMH. The first draft of the manuscript was written by TP, GRC, and DAM. All authors commented on the manuscript, and all authors read and approved the final manuscript.