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Article History

Accepted: 25 July 2024

First Online: 28 August 2024

Declarations

:

: This study was funded by Seagen Inc, which was acquired by Pfizer in December 2023, and by Astellas Pharma Inc.

: Mallory Farrar and Zsolt Hepp are former employees of, and held stock in Seagen Inc, which was acquired by Pfizer in December 2023. Lisa Mucha is an employee of Astellas Pharma Inc. Christine Michaels-Igbokwe, Sebastian Heidenreich, Katelyn Cutts, Nicholas Krucien, and Natasha Ramachandran are employees of Evidera, which received funding from Seagen Inc. and Astellas Inc. in connection with this study. Sebastian Heidenreich is an editorial board member of The Patient, and was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. Sebastian Heidenreich is also a minority stockholder of Thermo Fisher Scientific as part of his employment with Evidera. John L. Gore and David J. Benjamin have previously received consulting fees from Seagen Inc. Andrea B. Apolo and Nicholas I. Simon have no conflicts of interest to disclose. Authors of this manuscript include former employees of Seagen Inc, which was acquired by Pfizer in December 2023, and Astellas Pharma Inc.

: The data supporting the findings of this study are available within the article and its supplementary materials.

: The study protocol was approved by the Salus institutional review board (study number: 22147-01B). The study investigators were not employed by the study sponsors (Seagen Inc, which was acquired by Pfizer in December 2023, and Astellas Pharma Inc.), and any patient data were deidentified prior to being provided to study sponsors.

: Patients indicated their interest in participating and gave informed consent.

: Not applicable

: All software applications used are commercially available.

: Concept and design: Andrea B. Apolo, Christine Michaels-Igbokwe, Nicholas I. Simon, David J. Benjamin, Mallory Farrar, Zsolt Hepp, Lisa Mucha, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran, and John L. Gore; acquisition of data: Christine Michaels-Igbokwe, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, and Natasha Ramachandran; analysis and interpretation of data: Andrea B. Apolo, Christine Michaels-Igbokwe, Nicholas I. Simon, David J. Benjamin, Mallory Farrar, Zsolt Hepp, Lisa Mucha, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran, and John L. Gore; drafting of the manuscript: Andrea B. Apolo, Christine Michaels-Igbokwe, Nicholas I. Simon, David J. Benjamin, Mallory Farrar, Zsolt Hepp, Lisa Mucha, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran, and John L. Gore; critical revision of the paper for important intellectual content: Andrea B. Apolo, Christine Michaels-Igbokwe, Nicholas I. Simon, David J. Benjamin, Mallory Farrar, Zsolt Hepp, Lisa Mucha, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran, and John L. Gore; obtaining funding: Mallory Farrar, Zsolt Hepp, and Lisa Mucha; administrative, technical, or logistic support: Christine Michaels-Igbokwe, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran; and supervision: Andrea B. Apolo, Christine Michaels-Igbokwe, Nicholas I. Simon, David J. Benjamin, Mallory Farrar, Zsolt Hepp, Lisa Mucha, Sebastian Heidenreich, Katelyn Cutts, Nicolas Krucien, Natasha Ramachandran, and John L. Gore. All authors were involved in the design and conduct of the study, analysis and interpretation of the data, and preparation and review of the manuscript. All authors read and approved the final version of the manuscript.