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Article History

Accepted: 6 February 2025

First Online: 27 February 2025

Declarations

:

: The study was funded by Idorsia Pharmaceuticals Ltd. in accordance with Good Publication Practice (GPP) 2022 guidelines ().

: Evidera received research grants from Idorsia Pharmaceuticals Ltd. The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this article. The article has not received prior publication and is not under consideration for publication elsewhere.

: The datasets generated during and/or analyzed during the current study are not publicly available as the language in the patient informed consent does not permit the dataset to be made public.

: The study protocol was approved by Advarra Institutional Review Board (April 26, 2022; Pro00062506). Participants provided electronic informed consent prior to any study activities.

: TDM, AO, APB, LK, AS, KK, and MK contributed to the study conception and design. Material preparation, data collection, and analysis were performed by LK, AS, KK, and MK. All authors contributed to the drafting of the manuscript and approved the final manuscript.

: Miriam Kimel, PhD, is an employee of Evidera, which provides scientific consulting and other research services to pharmaceutical, device, government, and other non-government organizations. Leah Kleinman, Dr. PH, is an employee of Evidera, which provides scientific consulting and other research services to pharmaceutical, device, government, and other non-government organizations. Tobias Di Marco, PhD, is an employee of Idorsia Pharmaceuticals Ltd. Antonio Olivieri, MD, is an employee of Idorsia Pharmaceuticals Ltd. Andrea Schulz, MA, is an employee of Evidera, which provides scientific consulting and other research services to pharmaceutical, device, government, and other non-government organizations. Katherine Kirk, MA, is an employee of Evidera, which provides scientific consulting and other research services to pharmaceutical, device, government, and other non-government organizations. Andrea Phillips Beyer, PhD, is Director of Innovus Consulting Ltd, providing consulting services to the pharmaceutical industry.