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Article History

Accepted: 27 March 2025

First Online: 13 May 2025

Declarations

:

: This research was funded by Galderma.

: J.I.S. has received honoraria as a consultant or advisory board member for AbbVie, Aldena, Amgen, AOBiome, Arcutis, Arena, Asana, Aslan, Attovia, BiomX, Biosion, Bodewell, Boehringer-Ingelheim, Bristol Myers Squibb, Cara, Castle Biosciences, Celgene, Connect Biopharma, Corevitas, Dermavant, Eli Lilly, Galderma, GSK, Incyte, Kiniksa, LEO Pharma, MyOr Diagnostics, Nektar, Novartis, Optum, Pfizer, RAPT Therapeutics, Recludix, Regeneron, Sanofi-Genzyme, Shaperon, Target RWE, and Union Therapeutics and his institution has received grants from Galderma, Incyte, and Pfizer. O.C., K.J., C.P., R.S., and J.P. are employees of Galderma, which funded this study. D.F., C.D.B., and D.R. are employees of Evidera, which received financial support from Galderma for work on this study.

: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: N/A.

: Written informed consent to participate was sought prior to participation in the in-trial interview substudy.

: N/A.

: Jonathan I. Silverberg: writing—review and editing, visualization, and supervision; Dina Filipenko: conceptualization, methodology, software, validation, formal analysis, investigation, resources, data curation, writing—original draft, writing—review and editing, visualization, supervision, project administration, and funding acquisition; Carla Dias Barbosa: conceptualization, methodology, validation, formal analysis, investigation, resources, data curation, writing—original draft, writing—review and editing, visualization, supervision, project administration, and funding acquisition; Danielle Rodriguez: conceptualization, methodology, validation, formal analysis, investigation, resources, data curation, writing—review and editing, visualization, supervision, and project administration; Olivier Chambenoit: writing—review and editing, visualization, and funding acquisition; Katrin Jack: writing—review and editing, visualization, and funding acquisition; Christophe Piketty: writing—review and editing, visualization, supervision, and funding acquisition; Ram Subramanian: visualization, supervision, and funding acquisition; and Jorge Puelles: conceptualization, resources, writing—original draft, writing—review and editing, visualization, supervision, project administration, and funding acquisition. All authors approved the final version of the manuscript and agree to be accountable for the work.