Document is current

Article History

Accepted: 20 October 2024

First Online: 27 November 2024

Declarations

:

: This work was supported by the National Key Research and Development Program of China (2023YFC2706100), the National Natural Science Foundation of China (82173897), the Distinguished Young and Middle-aged Scholar of Shandong University, and the Taishan Scholar Program of Shandong Province (tstp20230660).

: Totsapol Jirasomprasert, Li-Yuan Tian, Dian-Ping You, Ya-Kun Wang, Lei Dong, Ya-Hui Zhang, Guo-Xiang Hao, John van den Anker, Yue-E Wu, Bo-Hao Tang, Wei Zhao, and Yi Zheng have no conflicts of interest that are directly relevant to the content of this article.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Approval was obtained from the institutional ethics committee.

: Written informed consent was obtained from all parents of the children included in the study.

: Not applicable.

: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: The research code is available from the corresponding author upon reasonable request.

: TJ analyzed and interpreted the data for the work, drafted the initial manuscript, and revised the manuscript. L-YT, D-PY, Y-KW, and LD collected the clinical data. G-XH and Y-HZ determined the samples. JvdA and Y-EW provided advice and critically reviewed and revised the manuscript. B-HT, WZ, and YZ contributed equally to the design of the work, supervised the data collection, and critically reviewed and revised the manuscript.