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Article History

Accepted: 18 May 2025

First Online: 4 June 2025

Declarations

:

: This work was financially supported by Stichting Coolsingel, Rotterdam, the Netherlands and Stichting Erasmus Fonds Pijngeneeskunde, Rotterdam, the Netherlands.

: Lonneke M. Staals, Jaap Dogger, Claudia Keyzer-Dekker, Anneke A. Boerlage, Eric F. Bokhorst, Jan J. van Wijk, Jeroen R. Scheepe, Monique van Dijk, Joost van Rosmalen, and Saskia N. de Wildt have no conflicts of interest that are directly relevant to the content of this article. Saskia N. de Wildt is an Editorial Board member of Pediatric Drugs. Sakia N. De Wildt was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.

: The Medical Ethics Committee of Erasmus MC (Chairperson Prof.dr. H.W. Tilanus) approved this study on 21 June, 2017 (MEC-2017-074). This study was conducted in compliance with the current revision of the Declaration of Helsinki.

: Written informed consent was obtained from all parents or legal guardians of the children included in the study.

: Not applicable.

: Data are available on reasonable request to the corresponding author.

: Not applicable.

: LMS: contributed to the design of the study, to the acquisition, analysis, and interpretation of the data, drafted the manuscript, revised it critically, and approved the final version for publication. JD: contributed to the acquisition and interpretation of the data, revised the work critically, and approved the final version for publication. CK-D: contributed to the acquisition and interpretation of the data, revised the work critically, and approved the final version for publication. AAB: contributed to the acquisition and interpretation of the data, revised the work critically, and approved the final version of the manuscript. EFB: contributed to the design of the study, the acquisition and interpretation of the data, revised the work critically, and approved the final version of the manuscript. JJvW: contributed to the acquisition and interpretation of the data, revised the work critically, and approved the final version of the manuscript. JRS: contributed to the acquisition and interpretation of the data, revised the work critically, and approved the final version of the manuscript. MvD: contributed to the design of the study and the interpretation of the data, revised the work critically, and approved the final version of the manuscript. JvR: this author contributed to the design of the study, to the analysis and interpretation of the data, revised the work critically, and approved the final version of the manuscript. SNdW: contributed to the design of the study, to the analysis and interpretation of the data, revised the work critically, and approved the final version of the manuscript. All authors agree to be accountable for all aspects of the work and ensure that questions related to the accuracy and integrity of any part of the work are appropriately investigated and resolved.