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Authors
van der Heijden, Joyce E. M. https://orcid.org/0000-0002-3584-2318
Gijsen, Violette https://orcid.org/0009-0001-3144-9359
van Uden, Anne M. https://orcid.org/0009-0009-3705-7864
de Hoop-Sommen, Marika https://orcid.org/0000-0003-1923-2111
Freriksen, Jolien J. M. https://orcid.org/0000-0002-4114-5412
Jacobs, Elke https://orcid.org/0000-0001-9955-0544
Greupink, Rick https://orcid.org/0000-0003-2599-7540
de Wildt, Saskia N. https://orcid.org/0000-0002-0502-0647
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Funding
Funding for this research was provided by:
Bill and Melinda Gates Foundation (INV-001822)
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Article History
Accepted: 2 June 2025
First Online: 2 July 2025
Declarations
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: This publication is based on research funded by the Bill & Melinda Gates Foundation (INV-001822). The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation.
: Prof. dr. de Wildt is a paid consultant for Khondrion and an editorial board member of Pediatric Drugs so was not involved in the selection of peer reviewers for the manuscript or any of the subsequent editorial decisions. All other authors have no conflicts of interest.
: Ethical approval was not required for this study as it was based solely on computer-based simulations and did not involve any human or animal subjects.
: Consent was not required for this study as it was based solely on computer-based simulations and did not involve any human or animal subjects.
: The raw data supporting the conclusions of this article will be made available by the authors without undue reservation.
: Simcyp PBPK software version 21 and version 22 (Certara UK Limited, Simcyp Division, Sheffield, UK).
: Not applicable.
: JH: Conceptualization, data curation, writing – original draft, and writing – review and editing. VG, JF, and EJ: Writing – review & editing. AU and MH-S: Data curation and writing – review & editing. RG and SW: Conceptualization and writing – review & editing.
