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Article History

Accepted: 1 August 2021

First Online: 8 October 2021

Declarations

:

: This study was funded by a grant from Otsuka.

: MAP, NH, CB, and CK are employees of OPEN Health and were paid consultants to Otsuka with regard to the development of this manuscript. HW, RAD, XW, and SM are employees of Otsuka. MAP, NH, CB, CK, HW, RAD, XW, and SM have no conflicts of interest that are directly relevant to the content of this article.

: Not applicable.

: Not applicable.

: Input data for the generation of the results are available in this article and its appendices.

: The presented model was built in R version 4.0.2, making use of the RxODE R package. R and RxODE are openly available and licensed under GPL-2/3. In addition, custom R code was developed by the authors.

: All authors adhered to the International Committee of Medical Journal Editors authorship criteria. MAP was the leading author who designed the pharmacoeconomic model and conducted the analyses together with CK. NH, CB, HW, RAD, XW, and SM contributed to the study design and interpretation of analysis. All authors reviewed the subsequent drafts and provided comments and the final approval of the manuscript for submission.