Document is current

Article History

Accepted: 16 September 2021

First Online: 18 October 2021

Declarations

:

: This study was sponsored by F. Hoffmann-La Roche Ltd, Basel, Switzerland.

: This article is published in a special edition journal supplement wholly funded by F. Hoffmann-La Roche Ltd.

: SHL and AL are employees of Acaster Lloyd Consulting Ltd, who were commissioned by F. Hoffmann-La Roche Ltd to conduct this study and therefore received a consulting fee to conduct the study presented in the article. CSS, YM and KG are employees of F. Hoffmann-La Roche Ltd. During the preparation of the manuscript, NP was employed by F. Hoffmann-La Roche. NP and KG are shareholders of F. Hoffmann-La Roche. CSS is a shareholder of Roche Holding AG. 

: The authors adhere to <i>General Data Protection Regulation</i> (GDPR) and UK Data Protection requirements, so will not make individual de-identified participant data available, as no consent to share the data publicly has been obtained; however, the study protocol will be made available upon request to the corresponding author.

: Not available.

: SHL and AL designed the study. SHL analyzed the data. SHL and AL interpreted the data and drafted the manuscript. NP and KG contributed to the design of the study, interpreted the data and revised the draft critically for important intellectual content. CSS and YM interpreted the data and revised the draft critically for important intellectual content. All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

: This study was reviewed and received exempt status determination by an independent review board, the Western Institutional Review Board (WIRB), on 6 June 2019 (submission number: #1-1190961-1), prior to participant recruitment.

: Freely given, informed consent to participate in the study was obtained from participants prior to participation in the study.

: Freely given, informed consent for the scientific publication of the results of this research was obtained from participants prior to participation in the study.