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Article History

Accepted: 25 April 2022

First Online: 18 July 2022

Declarations

:

: This study was funded by the National Natural Science Foundation of China (Grant no. 72174142). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.

: The authors have no conflicts of interest that are directly relevant to the content of this article.

: The study was granted ethical approval by the Academic Ethics Committee at Tianjin University (Reference No. TJUE-2021-168) and the Ethics Committee at Liaoning Institute of Basic Medicine (Reference No. 2020-01-5), and was conducted in accordance with the Declaration of Helsinki.

: Informed consent was obtained from all individual participants included in the study. Participants were informed about their freedom of refusal. Anonymity and confidentiality were maintained throughout the research process.

: Informed consent for publication was obtained from all individual participants. Participants were informed about their freedom of refusal for data publication. Anonymity and confidentiality were maintained in this publication.

: Not applicable.

: Not applicable.

: Concept and design: JW, KZ, and FX. Acquisition of data: JW, XH, PC, XL, and KZ. Analysis and interpretation of data: JW, XH, PC, SX, XL, HH, KZ, and FX. Drafting of the manuscript: JW, XH, PC, SX, and FX. Statistical analysis: JW, XH, PC, SX, and FX. Obtaining funding: JW, KZ, and FX. Supervision: JW, KZ, and FX. All authors critically reviewed previous versions of the manuscript and approved the final manuscript.