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Article History

Accepted: 1 October 2024

First Online: 11 November 2024

Declarations

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: All authors have read and approved the final version of this manuscript. JB, KH, GSF, GJ, AW, and HL were involved with the original conceptualisation. All authors contributed to the iteration of conceptualisation, methodology, workstreams, and investigation. JB, KH, GSF, JPS, RS, TP, GJ, JS, AW, ECB, and HL were involved in the formal analysis, writing, visualisation, and supervision.

: Pfizer Ltd. funded this study and the open access fees, including funding for the collaboration with Lane Clark & Peacock LLP. Pfizer Ltd. is the sponsor of the study. No specific grant or award funded this research.

: National datasets (including Cancer Informatics Solution - CaNISC, ChemoCare, Patient Episode Database for Wales -PEDW, NHS Wales Data Dictionary, Admitted Patient Care Data Set, Outpatient Activity Minimum Dataset, Emergency Department Data Set-EDDS, Births, Deaths and Marriages) and the trusted research environment, SeRP, are overseen by NHS Digital Health and Care Wales (DHCW). Queries should be sent directly to DHCW.

: NHS Wales Digital Health and Care Wales team currently oversees all extraction from national datasets into the linked dataset in the trusted research environment, SeRP.

: The authors have disclosed the following conflicts of interest: Burton: Study conducted while employed by Pfizer, Ltd. and may have held stock or stock options. Manuscript completed while self-employed at Patient-Centred Outcomes Consulting Ltd. Halsby: Employee of Pfizer and may hold stocks or stock options. Sáinz de la Fuente: Study conducted while employed by Pfizer, Ltd. and may have held stock or stock options. Currently employed at Teva Pharmaceutical Industries Ltd. Pearson-Stuttard: Partner & Head of Health Analytics at Lane Clark & Peacock LLP, Chair of the Royal Society for Public Health and reports personal fees from Pfizer Ltd outside of the submitted work. Sloan: No conflicts of interest to declare. Porter: Partner at Lane Clark & Peacock LLP and declares no further conflicts. John: No conflicts of interest to declare. Warburton: No conflicts of interest to declare. Selby: No conflicts of interest to declare. Povey: No conflicts of interest to declare. Chowdhury: Employee of Pfizer and may hold stocks or stock options. Bale: Received a stipend for professional consulting paid by Pfizer Ltd. for this research. Davies: Received a stipend for professional consulting paid by Pfizer Ltd. for this research. Clifton-Brown: Employee of Pfizer and may hold stocks or stock options. Laing: Employed by Swansea University which has received grant funding from Pfizer Ltd.

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