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Article History

Accepted: 19 January 2025

First Online: 8 February 2025

Declarations

:

: The COIN project is funded by the ZonMw ' Personalised Medicine' programme (project number 848101011), PGDX and CZ and this research was funded by the CAN.HEAL project through the European Commission EU4Health Program 2021–2027 under Grant No. 101080009.

: A.K., L.F.S., D.B., I.G.I., L.G.C., W.H.H., V.M.H.C., and V.P.R. declare no conflict of interest. R.J.A.F reports public private partnership consortia grants in collaboration with Labcorp (Personal Genome Diagnostics), Delfi Diagnostics, Solvias (Cergentis BV), MERCK BV, outside the submitted work. In addition, R.J.A.F. has several patents pending. E.S. reports lectures for Bio-Rad, Seracare, Roche, Biocartis, Illumina, Lilly, Janssen Cilag (Johnson&Johnson), AstraZeneca and Agena Bioscience; he is consultant in advisory boards for MSD/Merck, GSK, AstraZeneca, Astellas Pharma, Sysmex, Roche, Novartis, Bayer, BMS, Lilly, Amgen, Illumina, Agena Bioscience, Janssen Cilag (Johnson&Johnson), Sinnovisionlab, Diaceutics, CC Diagnostics; and received research grants from Biocartis, Invitae-ArcherDX, AstraZeneca, Agena Bio-science, BMS, Bio-Rad, Roche, Boehringer Ingelheim, CC Diagnostics, SNN/EFRO and Abbott (all paid to UMCG account); and travel reimbursements from Bio-Rad, Abbott, Illumina, Agena Bioscience, Roche, IQNPath and BioRAD. M.J.L.L. has had advisory roles (institutional) with AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Illumina, Janssen, Lilly, Merck Sharp & Dohme and Roche. G.A.M. is co-founder and board member (CSO) of CRCbioscreen BV, CSO of Health-RI (Dutch National Health Data infrastructure for research & innovation), and member of the supervisory board of IKNL (Netherlands Comprehensive Cancer Organisation). He has a research collaboration with CZ Health Insurances (cash matching to ZonMw grant) and he has research collaborations with Exact Sciences, Sysmex, Sentinel Ch. SpA, Personal Genome Diagnostics (PGDX), DELFi and Hartwig Medical Foundation; these companies provide materials, equipment and/or sample/genomic analyses.

: According to the Dutch Law on Medical Scientific Research (WMO), this study did not require approval by a medical ethics committee.

: All invited experts that participated in the expert roundtable consented before participating.

: Extracted literature findings are available in Online Resource 4 in the ESM. Transcripts of the expert roundtable will not be shared to ensure anonymity of the participants.

: AK, VC and VR developed the ideas and the methods for this study. AK and LS conducted the screening, the data extraction and the data analysis of the literature. AK, LS, VC, VR, and WH developed the first version of the recommendations. These recommendations were revised by all authors, after which AK and LS drafted the first version of the manuscript. The manuscript was reviewed in multiple rounds by all authors.