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Article History

Accepted: 11 March 2025

First Online: 29 March 2025

Declarations

:

: This research received no external funding.

: Medical writing support was provided by Colleen Dumont who is a writer employed by Cytel, and by Jane Adam, who is one of the co-authors.

: The authors declare that they have no conflicts of interest relevant to the content of this article.

: Statement on availability of data and materials is not applicable.

: This study did not require ethics approval as it did not involve human participants or animals.

: All authors contributed to the conception and design of the study. Bart Heeg conceptualized the paper’s content and drafted the manuscript. Dawn Lee provided critical review from an ERG perspective. Jane Adam offered critical revisions, particularly on HTA, clinical aspects, and biological plausibility. Maarten Postma provided critical revisions from an academic perspective. Mario Ouwens helped conceptualize the papers and contributed critical revisions. All authors read and approved the final manuscript.