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Authors
Briody, Jonathan https://orcid.org/0000-0002-0641-1551
Miller, Ian S. https://orcid.org/0000-0002-2673-9618
O’Mahony, James F. https://orcid.org/0000-0003-3414-7388
Tilson, Lesley
O’Farrell, Alice C. https://orcid.org/0000-0002-6732-2966
Chen, Qiushi https://orcid.org/0000-0003-4031-2669
Murphy, Verena https://orcid.org/0000-0003-3113-7854
Casey, Orla https://orcid.org/0000-0003-0097-1248
Schulte, Nadine https://orcid.org/0009-0002-4729-458X
Ebert, Matthias P. https://orcid.org/0000-0003-3228-5138
Prehn, Jochen H. M. https://orcid.org/0000-0003-3479-7794
Lambrechts, Diether https://orcid.org/0000-0002-3429-302X
Ylstra, Bauke https://orcid.org/0000-0001-9479-3010
Dienstmann, Rodrigo https://orcid.org/0000-0001-5997-318X
Byrne, Annette T. https://orcid.org/0000-0003-0287-8899
Bennett, Kathleen https://orcid.org/0000-0002-2861-7665
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Funding
Funding for this research was provided by:
Horizon 2020 (754923)
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Article History
Received: 18 September 2025
Accepted: 21 December 2025
First Online: 4 February 2026
Declarations
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: The authors declare no competing financial or nonfinancial interests that are directly or indirectly related to the work submitted for publication.
: This cost-effectiveness analysis used individual patient-level data from the ANGIOPREDICT consortium (ClinicalTrials.gov: NCT01822444). Institutional Review Board approval was obtained from the responsible Ethics Committees for all participating study centers as part of the ANGIOPREDICT and COLOSSUS projects.
: Written informed consent was obtained from all patients, and the biobank was approved by the local ethics board in accordance with the standards proposed by the Declaration of Helsinki.
: Not applicable.
: The source code for the open-source cost-effectiveness model developed for this study, usage instructions and study data are freely available under a Creative Commons license via , or through the following public repository: .
: Available here: .
: Conception/Design: Briody, Miller, O’Mahony, Tilson, O’Farrell, Chen, Murphy, Casey, Schulte, Ebert, Prehn, Lambrechts, Ylstra, Dienstmann, Byrne, Bennett. Provision of Study Material or Patients: Miller, Tilson, O’Farrell, Murphy, Casey, Ylstra, Dienstmann. Acquisition of Data: Briody, Miller, Tilson, Schulte, Ebert, Prehn, Lambrechts, Byrne. Analysis and Interpretation of Data: Briody, O’Mahony, Chen, Bennett. Drafting of the Manuscript: Briody, Byrne, Bennett. Critical Revision of Paper for Important Intellectual Content: Briody, Miller, O’Mahony, Tilson, O’Farrell, Chen, Murphy, Casey, Schulte, Ebert, Prehn, Lambrechts, Ylstra, Dienstmann, Byrne, Bennett. Statistical Analysis: Briody. Obtaining Funding: Byrne. Final Approval of Manuscript: All Authors.
