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Authors
Reitlo, Line Skarsem https://orcid.org/0000-0001-7153-7700
Pani, Jasmine https://orcid.org/0000-0002-3188-3585
Stensvold, Dorthe https://orcid.org/0000-0002-8942-1316
Wisløff, Ulrik https://orcid.org/0000-0002-7211-3587
Håberg, Asta Kristine https://orcid.org/0000-0002-9007-1202
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Clinical Trials BETA
Clinical trials referenced in this document:
nct01666340 at ClinicalTrials.govDocuments that mention this clinical trial
Long-Term Effects of a 5-Year Randomized Controlled Exercise Trial on Brain Volumes and Cognitive Function in Older Adults: A 4-Year Post-Intervention Follow-Up Study
https://doi.org/10.1007/s40279-026-02434-3
Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial
https://doi.org/10.1136/bmj.m3485
A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: study protocol for the Generation 100 study
https://doi.org/10.1136/bmjopen-2014-007519
Effects of 5-Year Exercise Training on Cognition in Older Adults: 10-Years Follow-Up from the Generation 100 Study
https://doi.org/10.1186/s40798-025-00956-0
Effects of 5 Years Aerobic Exercise on Cognition in Older Adults: The Generation 100 Study: A Randomized Controlled Trial
https://doi.org/10.1007/s40279-021-01608-5
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Funding
Funding for this research was provided by:
Norges Forskningsråd
Stiftelsen Kristian Gerhard Jebsen
Norges Teknisk-Naturvitenskapelige Universitet
Helse Midt-Norge RHF
St. Olavs Hospital Universitetssykehuset i Trondheim
Nasjonalforeningen for Folkehelsen
Helse- og Omsorgsdepartementet
NTNU Norwegian University of Science and Technology
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Article History
Accepted: 24 March 2026
First Online: 18 April 2026
Declarations
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: The authors declare no conflicts of interest.
: The study is still ongoing, and new data collection will be performed. Owing to privacy concerns and state regulations, the ethical and governance approvals for this study do not allow the MRI data and clinical and cognitive data to be made available in a public repository. Data in this manuscript can be accessed by qualified investigators after ethical and scientific review (to ensure the data are being requested for valid scientific research) and must comply with the European Union General Data Protection Regulations (GDPR), Norwegian laws and regulations, and NTNU regulations. The completion of a material transfer agreement (MTA) signed by an institutional official will be required.
: This study was approved by the Regional Committee for Medical Research Ethics, Central Norway (REC 2012/849). The study was performed in line with the principles of the Helsinki Declaration.
: Written informed consent was obtained from all participants included in the study.
: Not applicable.
: Not applicable.
: LSR contributed to the data collection, statistical analysis, figures, drafting, and revision of the manuscript. JP contributed to the statistical analyses and figures, and revised the manuscript. DS and UW supervised the RCT Generation 100 study, were responsible for the exercise and clinical data collection, and revised the manuscript. AKH supervised the Generation 100 Brain MRI and Cognition Substudy, organized the data collection, collected data, and drafted and revised the manuscript. All authors read and approved the final version of the manuscript.
