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Article History

Accepted: 15 April 2021

First Online: 10 May 2021

Declarations

:

: The authors gratefully acknowledge support from BioCartis under the terms of a collaborative research agreement that provided instrumentation and reagents. Funding was also provided through the James Graham Brown Cancer Center. SN Rai was partly supported with Wendell Cherry Chair in Clinical Trial Research Fund, multiple National Institutes of Health (NIH) grants (5P20GM113226, PI: McClain; 1P42ES023716, PI: Srivastava; 5P30GM127607-02, PI: Jones; 1P20GM125504-01, PI: Lamont; 2U54HL120163, PI: Bhatnagar/Robertson; 1P20GM135004, PI: Yan; 1R35ES0238373-01, PI: Cave; 1R01ES029846, PI: Bhatnagar; 1R01ES027778-01A1, PI: States; 1P30ES030283, PI: Sates), and Kentucky Council on Postsecondary Education grant (PON2 415 1900002934, PI: Chesney).

: Mark W. Linder, Michael E. Egger, Tracy Van Meter, Shesh N. Rai, Roland Valdes Jr., Melissa Barousse Hall, Xiaoyong Wu, Norah Alghamdi, and Jason A. Chesney have no conflicts of interest that are directly relevant to the content of this article.

: Plasma samples were collected by the James Graham Brown Cancer Center Multi-Disciplinary Melanoma Clinic biorepository at the University of Louisville under an ongoing IRB-approved protocol (IRB# 08.0388). This study was determined to be exempt from IRB review (reference number # 673708).

: All subjects enrolled were consented under the approved IRB protocol, University of Louisville IRB# 08.0388.

: Informed consent documentation included consent for publication of de-identified research data.

: The data that support the findings of this study are available on request from the corresponding author.

: Not applicable.

: ML: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, writing original draft. ME: data analysis, writing original draft. TV: formal analysis, writing original draft. SR: data analysis, writing original draft. RV: writing original draft. MH: data curation, writing original draft. XW: data analysis. NA: methodology. JC: conceptualization, formal analysis, resources.