Funding for this research was provided by:
Zhejiang Provincial Natural Science Foundation of China (LY23H050002)
Article History
Accepted: 16 October 2023
First Online: 16 November 2023
Declarations
:
: This study was supported by Zhejiang Provincial Natural Science Foundation of China [LY23H050002].
: The authors (Lijun Mou, Lina Zhu, Xujiao Chen, Ying Hu, Hong Zhu, Ying Xu) report that there are no competing interests to declare.
: The raw sequence data reported in this paper have been deposited in the Genome Sequence Archive (Genomics, Proteomics and Bioinformatics 2021) in the National Genomics Data Center (Nucleic Acids Res 2021), and China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (GSA: HRA004533) that are publicly accessible at ExternalRef removed. [CitationRef removed, CitationRef removed]. The data will be shared on reasonable request to the corresponding author.
: Study approval statement: This study protocol was reviewed and approved by the Ethics Committee of Zhejiang University School of Medicine Second Affiliated Hospital. The approval number was 2021-0427. Consent to participate statement: Written informed consents were obtained from all participants to participate in the study.
: Informed consents were obtained from all subjects involved in the study.
: Not applicable.
: Not applicable.
: Lijun Mou and Lina Zhu conceived the idea, and designed and planned the study; Xujiao Chen, Ying Hu, Hong Zhu, and Ying Xu gave important suggestions on study design and improved the study protocol; all authors participated in the collection of samples and the clinical data of patients; Ying Hu and Ying Xu analyzed the data; Lijun Mou and Lina Zhu drafted the manuscript and designed the figures; all authors discussed and interpreted the results, commented on the manuscript, provided critical feedback, and helped shape the research; and all authors read and approved the final manuscript.