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Article History

Accepted: 17 March 2024

First Online: 6 April 2024

Declarations

:

: This research received no external funding.

: Authors Raffaele Falsaperla, Vincenzo Sortino, Simona Domenica Marino, Ausilia Desiree Collotta, Carmela Gammeri, Federica Maria Sipala, Giovanni Li Volti, Martino Ruggieri, Simone Ronsisvalle declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

: R.F. and S.R. have conceived and designed the study. V.S., S.D.M., A.D.C, C.G., F.M.S. have acquired and analyzed the data and drafted the manuscript. S.R and F.M.S. have made the bioinformatics analysis. R.F. M.R., S.R., G.L.V., have critically reviewed the data. All authors have interpreted the data and have approved the submitted version.

: Data sharing not applicable to this article as no datasets were generated or analysed during the current study. All data generated or analysed during this study are included in this published article.

: Not applicable.

: This study was performed in line with the principles of the Declaration of Helsinki. Parents provided written consent to participate the study. Approval was granted by Azienda Ospedaliera Universitaria Policlinico "G.Rodolico-San Marco" Catania (10 May 2023/No. 26578).