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Article History

Accepted: 8 August 2024

First Online: 16 October 2024

Declarations

:

: Open access funding provided by Copenhagen University. The Molecular Unit received grants from the Mermaid III foundation and from Købmand Niels Erik Munk Pedersen Fonden (no. 2022-32-140-1). The laboratory of JBA was awarded an infrastructure grant from AP Møller and wife Chastine Mc-Kinney Møllers Foundation (no. 205216). CJO was awarded a postdoctoral fellowship from the European Union Marie Curie program – EpiTarget.

: The authors (DVNPO, EB, CJO, JLH, JBA, CH, and EH) have no conflicts of interest to declare.

: The study was carried out according to the guidelines of the Declaration of Helsinki, including written informed consent from all participants, and it has been approved by the Danish National Committee for Research Ethics, Capital Region (approval codes KF01-227/03 and KF01-143/04). All patients were followed until either death of any cause, emigration, or January 17th, 2015.

: Informed consent was obtained from all individual participants included in the study.

: Not applicable.

: The datasets (raw data) generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: Conceptualization: DVNPO, EH. Methodology: DVNPO, EH. Formal analysis: DVNPO, EB. Investigation: DVNPO, JLH. Resources: DVNPO, EH. Writing – original draft: DVNPO. Writing – review and editing: DVNPO, EB, CJO, JBA, CH, EH. Supervision: EH.