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Article History

Accepted: 23 October 2024

First Online: 8 November 2024

Declarations

:

: All authors: D.B., L.L.P., J.F., D.K.T., S.D.B., M.R.B., A.A., A.M., J.C., T.M. and M.V. declare no competing financial interests.

: The institutional review board of Bambino Gesù Children’s Hospital, IRCCS, Rome, approved the collection of blood samples for this research. All participants provided informed consent before study procedures.

: All authors have reviewed and given consent to this submission of this manuscript.

: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: This research was funded by the Ministry of Health of the Czech Republic, grant nr. NU23-03-00318; and by the Ministry of Education and Science of Bulgaria under the National Scientific Programme ‘Excellent Research and People for the Development of European Science’ 2021 (VIHREN) of the Bulgarian National Science Fund, contract #KP-06-DV/4 from 15 December 2021.

: J.C. and M.V. conceptualized the study; D.B. carried out the methodology; D.B., J.F., D.K.T., L.L.P. and M.R.B. carried out formal analysis and investigation; M.V. carried out writing—original draft preparation; D.B., A.A. and M.V. carried out writing—review and editing; J.F., J.C. and M.V. carried out funding acquisition; J.C., A.A., T.M., M.V. supervised the study.