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Article History

Accepted: 23 October 2024

First Online: 14 November 2024

Declarations

:

: No external funding was obtained for this study.

: RDH, MvD, KT, WdS, LFdGO, ASLPC, JB, ALV and PJKK declare no conflict of interest.

: The data presented in this study are available upon reasonable request from the corresponding author.

: The study protocol was approved by both the Gastroenterology Biobank Review Committee (protocol reference: 2020-16) and the local medical ethical review committee (protocol reference: B20.052). This study was conducted in compliance with the Dutch code of conduct for responsible use of human tissue in medical research. Tissue specimens and clinicopathological data were handled in anonymized manner and in compliance with the Declaration of Helsinki (1964).

: The need for informed consent was waived by the local medical ethical review committee.

: Not applicable.

: Not applicable.

: RDH was responsible for conceptualization, methodology, formal analysis and visualization, and wrote the original draft of the manuscript. KT and RDH conducted the immunohistochemical experiments, and RDH, MvD and ASLPC contributed to scoring of the immunohistochemical stainings. All remaining authors contributed to reviewing and editing the manuscript. PJKK supervised the study. All authors read and approved the final version of the manuscript.