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Article History

Accepted: 16 March 2025

First Online: 5 April 2025

Declarations

:

: All authors (S.S., V.T., A.B., M.U.S.S., P.K., S.R., M.J., C.S., P.S., N.M., S.N., P.R., A.J., G.P., A.K., P.M., and R.S.) declare that they have no conflicts of interests.

: S.S. designed the study, obtained ethical approval and funding, analyzed the data, and wrote the manuscript. V.T., A.S., P.K., and M.J. performed NGS testing. S.S. and P.S. performed and analyzed FISH. S.S. performed the bioinformatic analysis of NGS data. C.S., P.S., N.M., S.N., M.U.S.S., A.J., G.P., P.M., and R.D. provided clinical and laboratory data, reviewed them, and approved the manuscript. All authors agree to the content of the manuscript and its interpretations.

: This study was funded by an intramural research grant (IM/135/23-09-21-0114) from the Medical Education and Research Cell (MERC), Postgraduate Institute of Medical Education and Research (PGIMER), awarded to S.S.

: Data shall be shared upon reasonable request to the corresponding author.

: All procedures were conducted according to the ethical standards of the responsible committee on human experimentation (institutional and national) and the Helsinki Declaration of 1975, as revised in 2008. The research was carried out according to the institutional ethics guidelines after obtaining the approval of the institute’s ethics committee. The study did not involve any intervention based on the results of the study and did not involve any compensation for the participants. Written informed consent was obtained from all patients in this study.

: Not applicable.

: Not applicable.

: The work does not involve the use of any large language models (LLMs).

: Not applicable.