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Article History

Accepted: 13 April 2025

First Online: 16 May 2025

Declarations

:

: Open Access funding enabled and organized by Projekt DEAL. This work was supported by the German Research Foundation (DFG) VO 2138/7-1 grant 469177153, the DFG Heisenberg program VO 2138/8-1 grant 543719215, the DFG Collaborative Research Center 1690 (Project A03 to BV), and the Higher Education Commission (HEC) Pakistan under IRSIP Fellowship Program.

: M.S., A.B.M., L.N.M.V., A.A.A., B.K., A.E., Z.L., V.G., D.O., M.H.J., Z.Z., R.M., H.H., H.G.K., and B.V. have no conflicts of interest. All authors have read and agreed to the published version of the manuscript.

: This study was approved by the Institutional Review board of Mirpur University of Science and Technology, Mirpur AJK, Pakistan (approval number NO.ORIC/301/2023 dated 11-09-2023).

: Informed consent was obtained from all participants in the study, or from parents/legal guardians in the case of minors.

: After reviewing participant consent letters for publishing, the Institutional Review board of Mirpur University of Science and Technology, Mirpur AJK, Pakistan granted consent.

: The data supporting the findings of this study are available from the corresponding author, B.V., upon reasonable request. Variants have been submitted to ClinVar under SUB14945752.

: Not applicable.

: Conceptualization, M.S.; methodology, and software, B.V., M.S., L.M., A.E., A.B.M., R.M., B.K.,V.G., M.H.J., L.N.M.V. validation, B.V., D.O., Z.Z., L.N.M.V. writing—original draft preparation, M.S. writing—review and editing visualization, A.A.A., B.V., H.G.K., M.S. and supervision, A.A.A., Z.L., H.G.K., H.H., and B.V. All authors have read and agreed to the published version of the article.