Document is current
Any future updates will be listed below
-
Authors
Railean, Violeta
Rodrigues, Cláudia S.
Pankonien, Ines
Ramalho, Sofia S.
Silva, Iris A. L.
Doušová, Tereza
Castanhinha, Susana
Azevedo, Pilar
Roda, Juliana
Farinha, Carlos M. https://orcid.org/0000-0002-5467-1710
Amaral, Margarida D. https://orcid.org/0000-0002-0828-8630
-
Funding
Funding for this research was provided by:
Emily's Entourage
Fondazione per la Ricerca sulla Fibrosi Cistica (FFC#2/2023)
Fundação para a Ciência e a Tecnologia (UID/04046/2025)
European Union (H2020-SC1-2017-755021, EC HORIZON–MSCA-2023-DN-JD- 101120108)
Cystic Fibrosis Foundation (FARINH24G0)
Universidade de Lisboa
- License Information
-
More Information
Article History
Accepted: 29 July 2025
First Online: 13 September 2025
Declarations
:
: Open access funding provided by FCT|FCCN (b-on). The work was supported by the UID/04046/2025 centre grant (to BioISI), from FCT/MCTES Portugal, and research grants: “HIT-CF” (H2020-SC1-2017-755021) (to MDA), “ORGESTRA” (EC HORIZON–MSCA-2023-DN-JD- 101120108) [to MDA], both from European Union, FFC#2/2023 (to CMF) from Fondazione Fibrosi Cistica Ricerca, grant FARINH24G0 from the Cystic Fibrosis Foundation (to CMF), and a grant from Emily’s Entourage (to CMF). CR, IP, and VR were supported by FCT - Fundação para a Ciência e Tecnologia, I.P. (Portugal) by project references, UI/BD/153053/2022, DL57/2016/CP1479/CT0013, 2021.06718.BD, and DOI identifiers, , , , respectively, and also supported by FCT SSR by fellowship SFRH/BD/142857/2018 from the BioSys PhD programme PD/00065/2012. The Faculty of Sciences of the University of Lisboa’s Microscopy Facility is a node of the Portuguese Platform of BioImaging, reference PPBI-POCI-01-0145-FEDER-022122.
: Violeta Railean, Cláudia S. Rodrigues, Ines Pankonien, Sofia S. Ramalho, Iris A.L. Silva, Tereza Doušová, Susana Castanhinha, Pilar Azevedo, Juliana Roda, Carlos M. Farinha, and Margarida D. Amaral have no conflicts of interest that are directly relevant to the content of this article.
: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Hospital de Santa Maria, Lisbon, Portugal (DIRCLN-16JUL2014-211).
: Informed consent was obtained from all the subjects.
: Not applicable.
: All materials used will be made available upon request to the authors.
: Not applicable.
: All authors contributed to the study conception and design. Material preparation, data collection, and analyses were performed by VR, CR, SSR, IALS, IP, TD, SC, PA, and JR. The first draft of the manuscript was written by VR, CR, SSR, IP, and CMF. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
