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Article History

Accepted: 1 August 2025

First Online: 16 August 2025

Declarations

:

: This work was supported by grants from Karolinska Institutet Foundations (LS), Magnus Bergvall Foundation (LS), Region Uppsala (LS) and Cancerfonden (ET). The open access fee was sponsored by Uppsala University.

: Kristina Hellman, Mark Zupancic, Cecilia Jylhä, Emma Tham and Lars Sivars have no conflicts of interest that are directly relevant to the content of this article.

: The study was approved by the Ethical Review Board at Stockholm county, approval number 2016/2-31/1, with addendums 2016/1689-32, 2018/1472-32/1 and 2019-01222. The study was performed in accordance with the Declaration of Helsinki.

: Written informed consent was obtained from all patients.

: Not applicable.

: The data that support the findings of this study are not openly available because of reasons of sensitivity and are available from the corresponding author upon reasonable request.

: Not applicable.

: KH: investigation, conceptualisation, resources, formal analysis, writing (original draft), writing (review and editing). MZ: investigation, writing (review and editing). CJ: investigation, writing (review and editing). ET: conceptualisation, resources, formal analysis, funding acquisition, methodology, writing (review and editing). LS: conceptualisation, data curation, formal analysis, funding acquisition, investigation, visualisation, methodology, writing (original draft), writing (review and editing).