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Article History

Received: 2 October 2025

Accepted: 1 February 2026

First Online: 14 March 2026

Declarations

:

: GHS conceived the manuscript and led the drafting and organization of the content. SG, KE, SG, KDMcK, AR, PG, WFS, RC, MA, SG, KB, and LA contributed to the intellectual content of the manuscript and provided critical revisions. All authors reviewed and approved the final version of the manuscript.

: This article is the result of funding in part, owing to the contributions of government employees, by the National Institutes of Health (NIH). It is subject to the NIH Public Access Policy. Through acceptance of this federal funding, NIH has been given the right to make this article publicly available in PubMed Central upon the Official Date of Publication. Financial assistance was not used to conduct the study described in the article and/or used to assist with the preparation of the article. Financial assistance was not used to conduct the study described in the article and/or used to assist with the preparation of the article.

: Gloria Hopkins Sura, Kelly B. Engel, Sarah R. Greytak, Sandra M. Gaston, Kelsey Dillehay McKillip, Abhilasha Rao, Ping Guan, W. Fraser Symmans, Rachael Clark, Maria Arcila, Sayak Ghatak, and Lokesh Agrawal have no conflicts of interest that are directly relevant to the content of this article. Karol Bomsztyk is a co-founder, board member, and equity holder of Matchstick Technologies, Inc.

: Not applicable.

: Not applicable.

: Not applicable.

: Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

: Not applicable.