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Article History

Received: 24 November 2018

Accepted: 22 January 2019

First Online: 18 February 2019

Compliance with ethical standards

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: Dr. Tonelli has received funding from Abbott Laboratories in partnership with the Canadian Institutes of Health Research. The results presented in this paper have not been published previously in whole or part.

: All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The manuscript has not been submitted to any other journal for simultaneous consideration and has not been published previously (partly or in full). The present data are the full extent of our research and have not been split up into several parts. No data have been fabricated or manipulated (including images) to support our conclusions. No data, text, or theories by others are presented as if they were our own. Consent to submit has been received from all co-authors, as well as from the Department of Medicine at the University of Alberta. All authors on this submission have contributed sufficiently to the scientific work and share collective responsibility and accountability for the results.