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Article History

Received: 1 October 2018

Accepted: 29 October 2018

First Online: 28 November 2018

Compliance with ethical guidelines

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: U. Pieper-Fürst, V.-A. Dao and K. Shah-Hosseini declare that they have no competing interests. G. Panin is the R&D manager of PANIN S.R.L. (Rovigo, Italy). J. Lamprecht reports personal fees from Hulka S.R.L. (Rovigo, Italy). R. Mösges reports personal fees from ALK, grants from ASIT biotech, personal fees from Allergopharma, personal fees from Allergy Therapeutics, grants and personal fees from Bencard, grants from Leti, grants, personal fees and non-financial support from Lofarma, non-financial support from Roxall, grants and personal fees from Stallergenes, grants from Optima, personal fees from Friulchem, personal fees from Hexal, personal fees from Servier, personal fees from Klosterfrau, non-financial support from Atmos, personal fees from Bayer, non-financial support from Bionorica, personal fees from FAES, personal fees from GSK, personal fees from MSD, personal fees from Johnson & Johnson, personal fees from Meda, personal fees and non-financial support from Novartis, non-financial support from Otonomy, personal fees from Stada, personal fees from UCB, non-financial support from Ferrero, grants from BitopAG, grants from Hulka, personal fees from Nuvo, grants from Ursapharm outside the submitted work.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Declaration of Helsinki, as revised in 2013. Informed consent was obtained from all individual participants included in the study.